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  4. Ivermectin dosing strategy to achieve equivalent exposure coverage in children and adults
 
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Ivermectin dosing strategy to achieve equivalent exposure coverage in children and adults

Date Issued
2019-01-01
Author(s)
Brussee, Janneke M.  
Schulz, Jessica D.  
Coulibaly, Jean T.  
Keiser, Jennifer  
Pfister, Marc  
DOI
10.1002/cpt.1456
Abstract
Ivermectin is a commonly used broad-spectrum antiparasitic drug, yet doses that produce consistent exposure coverage across age have not been characterized, and no data are available in children weighing < 15 kg. First, a population pharmacokinetic model is developed based on data from 200 children and 11 adults, treated with 100-600 μg/kg ivermectin. Second, model-based simulations are performed to identify a dosing strategy that achieves equivalent exposure coverage in children and adults. Median (90% confidence interval) clearance of 0.346 (0.12-0.73) L/hour/kg in pre-school-aged (2-5 years) children is similar to 0.352 (0.17-0.69) L/hour/kg in school-aged (6-12 years) children but higher than in adults (0.199 (0.10-0.31) L/hour/kg), resulting in significantly lower exposure in children following a 200 μg/kg dose. Simulations indicate that a dose increase to 300 and 250 μg/kg in children aged 2-5 and 6-12 years, respectively, will achieve equivalent ivermectin exposure coverage in children and adults.
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