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Epidemiologie, Klinik, Diagnostik und Therapie von Infektionen durch Mycobacterium chimaera

Becker, S. L. and Schlotthauer, U. and Schäfers, H.-J. and Bals, R. and Trudzinski, F. C.. (2019) Epidemiologie, Klinik, Diagnostik und Therapie von Infektionen durch Mycobacterium chimaera. Pneumologie, 73 (8). pp. 474-481.

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Official URL: https://edoc.unibas.ch/71947/

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Abstract

The recognition, correct diagnosis and adequate clinical management of infections caused by atypical mycobacteria are challenging tasks in clinical practice. Invasive infections caused by; Mycobacterium chimaera; , a member of the; Mycobacterium avium-intracellulare; complex, have been increasingly reported over the past few years. Most infections occurred in patients who had undergone open-chest cardiothoracic surgery. Epidemiological and molecular studies showed that transmission of; M. chimaera; occurred through intraoperative aerosols derived from contaminated heater-cooler units, i. e. devices that are used to enable the extracardiac circuit in cardiothoracic surgery. Thus far, approximately 120 patient cases have been reported worldwide. The latency between exposure and onset of clinical symptoms may comprise several years. Clinical manifestations of; M. chimaera; infections include not only endocarditis and implant-associated infections, but also non-cardiac entities such as sarcoidosis-like symptoms, vertebral osteomyelitis and chorioretinitis. The pathogen can be detected in blood culture vials and in surgically obtained specimens from affected tissues, if specific microbiological tests for detection of mycobacteria are employed. There are no simple-to-use screening tests and a high clinical index of suspicion is thus mandatory in patients with previous exposure and compatible signs and symptoms. The successful treatment of; M. chimaera; infections requires the removal of infected devices and prolonged combination therapy with antimycobacterial drugs. This review summarises the clinical relevance, epidemiology, symptomatology, diagnosis and treatment of infections caused by; M. chimaera; , with a specific focus on pneumological aspects.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Becker, Sören Leif
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Thieme
ISSN:0934-8387
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:17 Sep 2019 13:38
Deposited On:17 Sep 2019 13:38

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