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Short-term associations between daily mortality and ambient particulate matter, nitrogen dioxide, and the air quality index in a Middle Eastern megacity

Amini, Heresh and Trang Nhung, Nguyen Thi and Schindler, Christian and Yunesian, Masud and Hosseini, Vahid and Shamsipour, Mansour and Hassanvand, Mohammad Sadegh and Mohammadi, Younes and Farzadfar, Farshad and Vicedo-Cabrera, Ana M. and Schwartz, Joel and Henderson, Sarah B. and Künzli, Nino. (2019) Short-term associations between daily mortality and ambient particulate matter, nitrogen dioxide, and the air quality index in a Middle Eastern megacity. Environmental Pollution, 254 (Pt B). p. 113121.

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Abstract

There is limited evidence for short-term association between mortality and ambient air pollution in the Middle East and no study has evaluated exposure windows of about a month prior to death. We investigated all-cause non-accidental daily mortality and its association with fine particulate matter (PM; 2.5; ), nitrogen dioxide (NO; 2; ), and the Air Quality Index (AQI) from March 2011 through March 2014 in the megacity of Tehran, Iran. Generalized additive quasi-Poisson models were used within a distributed lag linear modeling framework to estimate the cumulative effects of PM; 2.5; , NO; 2; , and the AQI up to a lag of 45 days. We further conducted multi-pollutant models and also stratified the analyses by sex, age group, and season. The relative risk (95% confidence interval (CI)) for all seasons, both sexes and all ages at lag 0 for PM; 2.5; , NO; 2; , and AQI were 1.004 (1.001, 1.007), 1.003 (0.999, 1.007), and 1.004 (1.001, 1.007), respectively, per inter-quartile range (IQR) increment (18.8 μg/m; 3; for PM; 2.5; , 12.6 ppb for NO; 2; , and 31.5 for AQI). In multi-pollutant models, the PM; 2.5; associations were almost independent from NO; 2; . However, the RRs for NO; 2; were slightly attenuated after adjustment for PM; 2.5; but they were still largely independent from PM; 2.5; . The cumulative relative risks (95% CI) per IQR increment reached maximum during the cooler months, including: 1.13 (1.06, 1.20) for PM; 2.5; at lag 0-31 (for females, all ages); 1.17 (1.10, 1.25) for NO; 2; at lag 0-45 (for males, all ages); and 1.13 (1.07, 1.20) for the AQI at lag 0-30 (for females, all ages). Generally, the RRs were slightly larger for NO; 2; than PM; 2.5; and AQI. We found somewhat larger RRs in females, age group >65 years of age, and in cooler months. In summary, positive associations were found in most models. This is the first study to report short-term associations between all-cause non-accidental mortality and ambient PM; 2.5; and NO; 2; in Iran.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Air Pollution and Health (Künzli)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics Frequentist Modelling
UniBasel Contributors:Amini, Heresh and Nguyen, Nguyen Anh and Schindler, Christian and Vicedo-Cabrera, Ana Maria and Künzli, Nino
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0269-7491
e-ISSN:1873-6424
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:17 Sep 2019 12:27
Deposited On:17 Sep 2019 12:27

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