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Analysis of microfluidic sample preparation for electron microscopy and single particle studies of interphotoreceptor retinoid-binding protein and leucine-rich repeat kinase 2

Albiez, Stefan. Analysis of microfluidic sample preparation for electron microscopy and single particle studies of interphotoreceptor retinoid-binding protein and leucine-rich repeat kinase 2. 2019, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_13301

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Abstract

The main goal of this thesis was the analysis of new methods for electron microscopy grid preparation and protein isolation focused on reducing the required sample volume without sacrificing EM grid quality and resolution, and on the application of cryo-EM and 3D reconstruction procedures for various single particle projects, including native human 20S proteasome, tobacco mosaic virus, interphotoreceptor retinoid-binding protein, and leucine-rich repeat kinase 2.
Advisors:Stahlberg, Henning and Engel, Andreas
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Stahlberg)
UniBasel Contributors:Stahlberg, Henning
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:13301
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:1 Online-Ressource (vi, 219 Seiten)
Language:English
Identification Number:
Last Modified:16 Nov 2019 05:30
Deposited On:15 Nov 2019 10:15

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