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Increased sensitivity to social exclusion during the luteal phase: Progesterone as resilience factor buffering against ostracism?

Lobmaier, Janek S. and Probst, Fabian and Lory, Vanda and Meyer, Andrea H. and Meinlschmidt, Gunther. (2019) Increased sensitivity to social exclusion during the luteal phase: Progesterone as resilience factor buffering against ostracism? Psychoneuroendocrinology, 107. pp. 217-224.

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Official URL: https://edoc.unibas.ch/71742/

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Abstract

A woman's social behaviour reportedly varies across the menstrual cycle. In this study, we estimated changes in sensitivity to social exclusion across the menstrual cycle and scrutinized the related role of progesterone. Forty-nine naturally cycling women played a virtual ball-tossing game (Cyberball) to manipulate social inclusion. All participants underwent inclusion and exclusion conditions during the late follicular and the luteal phase. We assessed salivary progesterone concentrations at each cycle phase. After each Cyberball session we measured positive/negative mood using the Multidimensional Mood State Questionnaire (MDMQ). Multilevel analyses indicated that women showed worse mood following exclusion as compared to inclusion conditions (p = 0.014). Notably, this exclusion effect was more pronounced during the luteal phase than the late follicular phase (p = 0.029). As expected, progesterone concentrations were higher during the luteal phase as compared to the late follicular phase, but interestingly, progesterone concentrations were negatively associated with exclusion effects. When accounting for mediation via progesterone, direct cycle-phase related differences in social exclusion effects even increased as compared to the model without mediator. These findings suggest that progesterone may function as buffer against negative feelings that result from being socially excluded. The relevance of these findings for Premenstrual Dysphoric Disorder (PMDD) are discussed, and we conclude that social exclusion may represent an important research domain criterion (RDoC) of relevance for PMDD, with progesterone pointing to new potential pharmacological targets.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Psychosomatik > Psychosomatik (Schäfert)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Psychosomatik > Psychosomatik (Schäfert)
07 Faculty of Psychology
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Meyer, Andrea Hans and Meinlschmidt, Gunther
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0306-4530
e-ISSN:1873-3360
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:28 Sep 2020 09:28
Deposited On:18 Sep 2019 14:11

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