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Definitions and guidelines for research on antibiotic persistence

Balaban, Nathalie Q. and Helaine, Sophie and Lewis, Kim and Ackermann, Martin and Aldridge, Bree and Andersson, Dan I. and Brynildsen, Mark P. and Bumann, Dirk and Camilli, Andrew and Collins, James J. and Dehio, Christoph and Fortune, Sarah M. and Ghigo, Jean-Marc and Hardt, Wolf-Dietrich and Harms, Alexander and Heinemann, Matthias and Hung, Deborah T. and Jenal, Urs and Levin, Bruce R. and Michiels, Jan and Storz, Gisela and Tan, Man-Wah and Tenson, Tanel and Van Melderen, Laurence and Zinkernagel, Annelies. (2019) Definitions and guidelines for research on antibiotic persistence. Nature Reviews Microbiology, 17 (7). pp. 441-448.

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Official URL: https://edoc.unibas.ch/71590/

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Abstract

Increasing concerns about the rising rates of antibiotic therapy failure and advances in single-cell analyses have inspired a surge of research into antibiotic persistence. Bacterial persister cells represent a subpopulation of cells that can survive intensive antibiotic treatment without being resistant. Several approaches have emerged to define and measure persistence, and it is now time to agree on the basic definition of persistence and its relation to the other mechanisms by which bacteria survive exposure to bactericidal antibiotic treatments, such as antibiotic resistance, heteroresistance or tolerance. In this Consensus Statement, we provide definitions of persistence phenomena, distinguish between triggered and spontaneous persistence and provide a guide to measuring persistence. Antibiotic persistence is not only an interesting example of non-genetic single-cell heterogeneity, it may also have a role in the failure of antibiotic treatments. Therefore, it is our hope that the guidelines outlined in this article will pave the way for better characterization of antibiotic persistence and for understanding its relevance to clinical outcomes.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Microbiology (Harms)
UniBasel Contributors:Harms, Alexander and Bumann, Dirk and Dehio, Christoph and Jenal, Urs
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
ISSN:1740-1526
e-ISSN:1740-1534
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:17 Aug 2020 15:33
Deposited On:17 Aug 2020 15:33

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