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Imaging of post-mortem human brain tissue using electron and X-ray microscopy

Lewis, Amanda J. and Genoud, Christel and Pont, Mélissa and Van de Berg, Wilma DJ and Frank, Stephan and Stahlberg, Henning and Shahmoradian, Sarah H. and Al-Amoudi, Ashraf. (2019) Imaging of post-mortem human brain tissue using electron and X-ray microscopy. Current Opinion in Structural Biology, 58. pp. 138-148.

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Official URL: https://edoc.unibas.ch/71549/

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Abstract

Electron microscopy imaging of post-mortem human brain (PMHB) comes with a unique set of challenges due to numerous parameters beyond the researcher's control. Nevertheless, the wealth of information provided by the ultrastructural analysis of PMHB is proving crucial in our understanding of neurodegenerative diseases. This review highlights the importance of such studies and covers challenges, limitations and recent developments in the application of current EM imaging, including cryo-ET and correlative hybrid techniques, on PMHB.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Stahlberg)
UniBasel Contributors:Stahlberg, Henning
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0959-440X
e-ISSN:1879-033X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:17 Aug 2020 14:58
Deposited On:17 Aug 2020 14:58

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