No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions

Wellendorph, Petrine and Johansen, Lars Dan and Jensen, Anders A. and Casanova, Emilio and Gassmann, Martin and Deprez, Pierre and Clément-Lacroix, Philippe and Bettler, Bernhard and Bräuner-Osborne, Hans. (2009) No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. Journal of molecular endocrinology, Vol. 42, no. 3. pp. 215-223.

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Official URL: http://edoc.unibas.ch/dok/A5262211

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GPRC6A is a seven-transmembrane receptor mediating signaling by a wide range of L-alpha-amino acids, a signaling augmented by the divalent cations Ca(2)(+) and Mg(2)(+). GPRC6A transcripts are detected in numerous mammalian tissues, but the physiological role of the receptor is thus far elusive. Analogously to the closely related calcium-sensing receptor, GPRC6A has been proposed to function as a metabolic sensor of Ca(2)(+) and amino acids in bone and other tissues. In the present study, we have generated the first GPRC6A knockout mice and studied their phenotype with particular focus on bone homeostasis. The generated GPRC6A knockout mice are viable and fertile, develop normally, and exhibit no significant differences in body weight compared with wild-type littermates. Assessment of bone mineral density, histomorphometry, and bone metabolism demonstrated no significant differences between 13-week-old knockout and wild-type mice. In conclusion, our data do not support a role for GPRC6A in normal bone physiology.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Molecular Neurobiology Synaptic Plasticity (Bettler)
UniBasel Contributors:Bettler, Bernhard
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Society for Endocrinology
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Jan 2013 08:37
Deposited On:22 Mar 2012 13:37

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