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Short- and Long-Term Effects of Bariatric Surgery on Vascular Phenotype

Streese, Lukas and Königstein, Karsten and Goricki, Lara and Infanger, Denis and Wölnerhanssen, Bettina and Peters, Thomas and Schmidt-Trucksäss, Arno and Hanssen, Henner. (2019) Short- and Long-Term Effects of Bariatric Surgery on Vascular Phenotype. Obesity surgery, 29 (4). pp. 1301-1308.

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Official URL: https://edoc.unibas.ch/71513/

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Abstract

Retinal microvascular diameters and large artery stiffness are valid biomarkers of cardiovascular risk. This study assessed short- and long-term micro- and macrovascular improvements after bariatric surgery (BS).; Sixteen patients (44 ± 12 years) underwent BS in this observational study. Two weeks before as well as 6 weeks and 4 years after surgery, retinal vessel analysis and assessment of brachial-ankle pulse wave velocity (baPWV), cardio-ankle vascular index (CAVI), and anthropometry were performed. Three patients were lost to follow-up.; Six weeks after BS, retinal arteriolar diameters (CRAE) were wider (180.1 μm vs. 188.1 μm; p = 0.001), and the arteriolar-to-venular diameter ratio (AVR) was higher (0.82 vs. 0.86; p < 0.001) compared to baseline levels. During the 4 years of follow-up, the retinal changes sustained but further improvements did not occur. Both indices of large artery stiffness, baPWV and CAVI, remained unchanged 6 weeks and 4 years after surgery.; Retinal microvascular phenotype improved 6 weeks after BS. The improvements in microvascular health were maintained during 4 years of follow-up but, despite significant further reductions in body mass index, did not improve further long-term. baPWV and CAVI were unaffected after surgery indicating that BS primarily affects microvascular phenotype rather than large artery stiffness. Retinal vessel imaging seems to be a feasible diagnostic tool to monitor microvascular health after BS. Normalization of BMI and blood pressure may be necessary to achieve long-term improvement of large artery phenotype after BS.
Faculties and Departments:03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sport- und Bewegungsmedizin > Präventive Sportmedizin (Hanssen)
UniBasel Contributors:Streese, Lukas and Schmidt-Trucksäss, Arno
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer
ISSN:0960-8923
e-ISSN:1708-0428
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:08 Jul 2020 13:09
Deposited On:08 Jul 2020 13:09

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