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In patients suffering from major depressive disorders, quantitative EEG showed favorable changes in left and right prefrontal cortex

Haghighi, Mohammad and Ludyga, Sebastian and Rahimi, Boshra and Jahangard, Leila and Ahmadpanah, Mohammad and Torabian, Saadat and Esnaashari, Farzaneh and Nazaribadie, Marzieh and Bajoghli, Hafez and Sadeghi Bahmani, Dena and Holsboer-Trachsler, Edith and Brand, Serge. (2017) In patients suffering from major depressive disorders, quantitative EEG showed favorable changes in left and right prefrontal cortex. Psychiatry research, 251. pp. 137-141.

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Official URL: https://edoc.unibas.ch/71397/

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Abstract

Patients suffering from major depressive disorders (MDD) report anhedonia, low concentration and lack of goal-oriented behavior. Data from imaging and quantitative EEG (QEEG) studies show an asymmetry in the prefrontal cortex (PFC), with lower left as compared to right PFC-activity, associated with specific depression-related behavior. Cordance is a QEEG measurement, which combines absolute and relative power of EEG-spectra with strong correlations with regional perfusion. The aim of the present study was to investigate to what extent a four weeks lasting treatment with a standard SSRI had an influence on neuronal activation and MDD-related symptoms.; Twenty patients suffering from severe MDD were treated with citalopram (40mg) for four consecutive weeks. At baseline and at the end of the treatment, patients underwent QEEG. Experts rated the degree of depression with the Hamilton Depression Rating Scale (HDRS).; Over time, theta cordance increased over right ventromedial and left dorsolateral PFC, whereas alpha cordance decreased over dorsolateral PFC. Improvement in MDD-related symptoms was higher in patients showing decreased EEG theta cordance over right dorsal PFC and increased EEG alpha cordance over left dorsolateral PFC.; In patients suffering from MDD, treatment response was associated with favorable changes in neuronal activity.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sportwissenschaft > Sportwissenschaften (PĆ¼hse)
UniBasel Contributors:Brand, Serge
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1872-7123
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:05 Oct 2019 11:28
Deposited On:05 Oct 2019 11:28

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