1,4-Palladium Shift/C(sp(3))-H Activation Strategy for the Remote Construction of Five-Membered Rings

1,n-Metal shift is an elegant alternative approach enabling the functionalization of remote C H bonds from simple precursors. In this work, we report a novel and simple Pd-0-catalyzed domino reaction involving 1,4-palladium shift and C(sp(3))-H activation and leading to (fused) five-membered rings. This method allowed access to a broad range of valuable arylidene gamma-lactams and indanones and was applied to the formal synthesis of (-)-pyrrolam.