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Association between long-term air pollution exposure and DNA methylation : The REGICOR study

Sayols-Baixeras, Sergi and Fernández-Sanlés, Alba and Prats-Uribe, Albert and Subirana, Isaac and Plusquin, Michelle and Künzli, Nino and Marrugat, Jaume and Basagaña, Xavier and Elosua, Roberto. (2019) Association between long-term air pollution exposure and DNA methylation : The REGICOR study. Environmental research, 176. p. 108550.

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Official URL: https://edoc.unibas.ch/71299/

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Abstract

Limited evidence suggests that epigenetic mechanisms may partially mediate the adverse effects of air pollution on health. Our aims were to identify new genomic loci showing differential DNA methylation associated with long-term exposure to air pollution and to replicate loci previously identified in other studies.; A two-stage epigenome-wide association study was designed: 630 individuals from the REGICOR study were included in the discovery and 454 participants of the EPIC-Italy study in the validation stage. DNA methylation was assessed using the Infinium HumanMethylation450 BeadChip. NOX, NO2, PM10, PM2.5, PMcoarse, traffic intensity and traffic load exposure were measured according to the ESCAPE protocol. A systematic review was undertaken to identify those cytosine-phosphate-guanine (CpGs) associated with air pollution in previous studies and we screened for them in the discovery study.; In the discovery stage of the epigenome-wide association study, 81 unique CpGs were associated with air pollution (p-value <10; -5; ) but none of them were validated in the replication sample. Furthermore, we identified 15 CpGs in the systematic review showing differential methylation with a p-value fulfilling the Bonferroni criteria and 1673 CpGs fulfilling the false discovery rate criteria, all of which were related to PM; 2.5; or NO; 2; . None of them was replicated in the discovery study, in which the top hits were located in an intergenic region on chromosome 1 (cg10893043, p-value = 6.79·10; -5; ) and in the LRRC45 and PXK genes (cg05088605, p-value = 2.15·10; -04; ; cg16560256, p-value = 2.23·10; -04; ).; Neither new genomic loci associated with long-term air pollution were identified, nor previously identified loci were replicated. Continued efforts to test this potential association are warranted.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Air Pollution and Health (Künzli)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Künzli, Nino
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0013-9351
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 Jul 2019 13:52
Deposited On:10 Jul 2019 13:52

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