Ferenc, Alena. Analysis of protein modifications in biopharmaca by capillary electrophoresis and high-performance liquid chromatography : monitoring deamidation, charge variant distribution, and PEGylation. 2017, Doctoral Thesis, University of Basel, Faculty of Science.
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Official URL: http://edoc.unibas.ch/diss/DissB_13252
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Abstract
This thesis focuses on the analysis of protein modifications and protein isoforms in biopharmaceuticals. It evaluates the potential of HPLC-UV, HPLC-ESI-MS, CE-UV and CE-ESI-MS methods, when optimized and used together with specific enzymatic treatments, for characterizing protein modifications like deamidation, modifications leading to a shift in the charge pattern, and on PEGylation.
| Advisors: | Hauser, Peter C. and Schwarz, Maria Anna and Rizzi, Andreas |
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| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Analytische Chemie (Hauser) |
| UniBasel Contributors: | Hauser, Peter C. |
| Item Type: | Thesis |
| Thesis Subtype: | Doctoral Thesis |
| Thesis no: | 13252 |
| Thesis status: | Complete |
| Number of Pages: | 1 Online-Ressource (162 Seiten) |
| Language: | English |
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| Last Modified: | 06 Sep 2019 04:30 |
| Deposited On: | 05 Sep 2019 08:34 |
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