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PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation

Karunakaran, Smitha and Chowdhury, Ananya and Donato, Flavio and Quairiaux, Charles and Michel, Christoph M. and Caroni, Pico. (2016) PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation. Nature neuroscience, 19 (3). pp. 454-464.

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Official URL: https://edoc.unibas.ch/71197/

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Abstract

Long-term consolidation of memories depends on processes occurring many hours after acquisition. Whether this involves plasticity that is specifically required for long-term consolidation remains unclear. We found that learning-induced plasticity of local parvalbumin (PV) basket cells was specifically required for long-term, but not short/intermediate-term, memory consolidation in mice. PV plasticity, which involves changes in PV and GAD67 expression and connectivity onto PV neurons, was regulated by cAMP signaling in PV neurons. Following induction, PV plasticity depended on local D1/5 dopamine receptor signaling at 0-5 h to regulate its magnitude, and at 12-14 h for its continuance, ensuring memory consolidation. D1/5 dopamine receptor activation selectively induced DARPP-32 and ERK phosphorylation in PV neurons. At 12-14 h, PV plasticity was required for enhanced sharp-wave ripple densities and c-Fos expression in pyramidal neurons. Our results reveal general network mechanisms of long-term memory consolidation that requires plasticity of PV basket cells induced after acquisition and sustained subsequently through D1/5 receptor signaling.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Neurobiology (Donato)
UniBasel Contributors:Donato, Flavio
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1546-1726
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:17 May 2020 20:11
Deposited On:17 May 2020 20:11

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