edoc

Early- and late-born parvalbumin basket cell subpopulations exhibiting distinct regulation and roles in learning

Donato, Flavio and Chowdhury, Ananya and Lahr, Maria and Caroni, Pico. (2015) Early- and late-born parvalbumin basket cell subpopulations exhibiting distinct regulation and roles in learning. Neuron, 85 (4). pp. 770-786.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/71196/

Downloads: Statistics Overview

Abstract

Brain networks can support learning by promoting acquisition of task-relevant information or by adhering to validated rules, but the mechanisms involved are poorly understood. Upon learning, local inhibitory parvalbumin (PV)-expressing Basket cell networks can switch to opposite configurations that either favor or interfere with further learning, but how this opposite plasticity is induced and relates to distinct learning requirements has remained unclear. Here, we show that PV Basket cells consist of hitherto unrecognized subpopulations, with distinct schedules of neurogenesis, input connectivities, output target neurons, and roles in learning. Plasticity of hippocampal early-born PV neurons was recruited in rule consolidation, whereas plasticity of late-born PV neurons was recruited in new information acquisition. This involved regulation of early-born neuron plasticity specifically through excitation, and of late-born neuron plasticity specifically through inhibition. Therefore, opposite learning requirements are implemented by distinct local networks involving PV Basket cell subpopulations specifically regulated through inhibition or excitation.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Neurobiology (Donato)
UniBasel Contributors:Donato, Flavio
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1097-4199
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:23 May 2020 16:08
Deposited On:23 May 2020 16:08

Repository Staff Only: item control page