Structural plasticity upon learning: regulation and functions

Caroni, Pico and Donato, Flavio and Muller, Dominique. (2012) Structural plasticity upon learning: regulation and functions. Nature reviews. Neuroscience, 13 (7). pp. 478-490.

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Official URL: https://edoc.unibas.ch/71193/

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Recent studies have provided long-sought evidence that behavioural learning involves specific synapse gain and elimination processes, which lead to memory traces that influence behaviour. The connectivity rearrangements are preceded by enhanced synapse turnover, which can be modulated through changes in inhibitory connectivity. Behaviourally related synapse rearrangement events tend to co-occur spatially within short stretches of dendrites, and involve signalling pathways partially overlapping with those controlling the functional plasticity of synapses. The new findings suggest that a mechanistic understanding of learning and memory processes will require monitoring ensembles of synapses in situ and the development of synaptic network models that combine changes in synaptic function and connectivity.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Neurobiology (Donato)
UniBasel Contributors:Donato, Flavio
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Nov 2020 09:16
Deposited On:10 Nov 2020 09:16

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