EphA4 signaling in juveniles establishes topographic specificity of structural plasticity in the hippocampus

Galimberti, Ivan and Bednarek, Ewa and Donato, Flavio and Caroni, Pico. (2010) EphA4 signaling in juveniles establishes topographic specificity of structural plasticity in the hippocampus. Neuron, 65 (5). pp. 627-642.

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Official URL: https://edoc.unibas.ch/71191/

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The formation and loss of synapses is involved in learning and memory. Distinct subpopulations of permanent and plastic synapses coexist in the adult brain, but the principles and mechanisms underlying the establishment of these distinctions remain unclear. Here we show that in the hippocampus, terminal arborizations (TAs) with high plasticity properties are specified at juvenile stages, and account for most synapse turnover of adult mossy fibers. Out of 9-12 giant terminals along CA3, distinct subpopulations of granule neurons revealed by mouse reporter lines exhibit 0, 1, or >2 TAs. TA specification involves a topographic rule based on cell body position and EphA4 signaling. Upon disruption of EphA4 signaling or PSA-NCAM in juvenile circuits, single-TA mossy fibers establish >2 TAs, suggesting that intra-axonal competition influences plasticity site selection. Therefore, plastic synapse specification in juveniles defines sites of synaptic remodeling in the adult, and hippocampal circuit plasticity follows unexpected topographic principles.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Neurobiology (Donato)
UniBasel Contributors:Donato, Flavio
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Nov 2020 09:12
Deposited On:10 Nov 2020 09:12

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