Laboratory findings, compassionate use of favipiravir, and outcome in patients with Ebola virus disease, Guinea, 2015 - a retrospective observational study

Kerber, Romy and Lorenz, Eva and Duraffour, Sophie and Sissoko, Daouda and Rudolf, Martin and Jaeger, Anna and Cisse, Sekou Ditinn and Camara, Alseny-Modet and Miranda, Osvaldo and Castro, Carlos M. and Akoi Bore, Joseph and Raymond Koundouno, Fara and Repits, Johanna and Afrough, Babak and Becker-Ziaja, Beate and Hinzmann, Julia and Mertens, Marc and Vitoriano, Ines and Hugh Logue, Christopher and Böttcher, Jan-Peter and Pallasch, Elisa and Sachse, Andreas and Bah, Amadou and Cabeza-Cabrerizo, Mar and Nitzsche, Katja and Kuisma, Eeva and Michel, Janine and Holm, Tobias and Zekeng, Elsa Gayle and Cowley, Lauren A. and Garcia-Dorival, Isabel and Hetzelt, Nicole and Baum, Jonathan Hans Josef and Portmann, Jasmine and Carter, Lisa and Yenamaberhan, Rahel Lemma and Camino, Alvaro and Enkirch, Theresa and Singethan, Katrin and Meisel, Sarah and Mazzarelli, Antonio and Kosgei, Abigail and Kafetzopoulou, Liana and Rickett, Natasha Y. and Patrono, Livia Victoria and Ghebreghiorghis, Luam and Arnold, Ulrike and Colin, Géraldine and Juchet, Sylvain and Marchal, Claire Levy and Kolie, Jacques Seraphin and Beavogui, Abdoul Habib and Wurr, Stephanie and Bockholt, Sabrina and Krumkamp, Ralf and May, Jürgen and Stoecker, Kilian and Fleischmann, Erna and Ippolito, Giuseppe and Carroll, Miles W. and Koivogui, Lamine and Magassouba, N'Faly and Keita, Sakoba and Gurry, Céline and Drury, Patrick and Diallo, Boubacar and Formenty, Pierre and Wölfel, Roman and Caro, Antonino Di and Gabriel, Martin and Anglaret, Xavier and Malvy, Denis and Günther, Stephan. (2019) Laboratory findings, compassionate use of favipiravir, and outcome in patients with Ebola virus disease, Guinea, 2015 - a retrospective observational study. Journal of infectious diseases, 220 (2). pp. 195-202.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/71188/

Downloads: Statistics Overview

Abstract

In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea, confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold (Ct) of an Ebola virus-specific reverse transcription-polymerase chain reaction assay and 13 blood chemistry parameters were measured on admission and during hospitalization. Favipiravir treatment was offered to patients with EVD on a compassionate-use basis.; To reduce biases in the raw field data, we carefully selected 163 of 286 patients with EVD for a retrospective study to assess associations between potential risk factors, alterations in blood chemistry findings, favipiravir treatment, and outcome.; The case-fatality rate in favipiravir-treated patients was lower than in untreated patients (42.5% [31 of 73] vs 57.8% [52 of 90]; P = .053 by univariate analysis). In multivariate regression analysis, a higher Ct and a younger age were associated with survival (P < .001), while favipiravir treatment showed no statistically significant effect (P = .11). However, Kaplan-Meier analysis indicated a longer survival time in the favipiravir-treated group (P = .015). The study also showed characteristic changes in blood chemistry findings in patients who died, compared with survivors.; Consistent with the JIKI trial, this retrospective study revealed a trend toward improved survival in favipiravir- treated patients; however, the effect of treatment was not statistically significant, except for its influence on survival time.

Faculties and Departments:	09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Swiss Centre for International Health (SCIH)
UniBasel Contributors:	Bah, Amadou
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Oxford University Press
ISSN:	0022-1899
Note:	Publication type according to Uni Basel Research Database: Journal article
Identification Number:	doi: 10.1093/infdis/jiz078 pmid: 30788508
Last Modified:	10 Jul 2019 13:39
Deposited On:	10 Jul 2019 13:39

Repository Staff Only: item control page