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Adrenaline-induced chronic ocular hypertension in adult rabbits

Mikheytseva, I. and Lipovetskaya, E. and Kopp, O. and Mozaffarieh, M. and Grieshaber, M. C. and Flammer, J. and Meyer, P.. (2009) Adrenaline-induced chronic ocular hypertension in adult rabbits. Klinische Monatsblätter für Augenheilkunde, Vol. 226, H. 4. pp. 332-336.

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Official URL: http://edoc.unibas.ch/dok/A5252352

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Abstract

BACKGROUND: The aim of this study was to develop a new animal model to enhance our understanding of the biological pathomechanisms involved in glaucoma. MATERIALS AND METHODS: Forty white giant rabbits were divided into a treated (N = 30) and a control group (N = 10). Boli of adrenaline hydrochloride (0.1 mL 0.1% solution) were repeatedly injected into the veins of the ears of the rabbits and physiological saline in the control group, respectively, for three months. Intraocular pressure (IOP) and outflow facility of the aqueous humour were measured prior to, during and after treatment (4-6 months, 7-9 months, 10-12 months). RESULTS: In comparison to the control group, the adrenaline-treated group showed a significant increase in IOP both during treatment (25%) and 12 months after treatment (57%). Comparative analysis further showed that the aqueous humour outflow facility of the treated group increased by 16.5% during the treatment, and showed a continuous decrease of 60 % after treatment. CONCLUSION: This rabbit model could be useful for further investigations of the pathomechanisms involved in glaucoma.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Ophthalmologie (Flammer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Ophthalmologie (Flammer)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Ocular Pharmacology and Physiology (Neutzner/Meyer)
UniBasel Contributors:Flammer, Josef and Meyer, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Thieme
ISSN:0023-2165
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:45
Deposited On:22 Mar 2012 13:37

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