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Proenkephalin for the early detection of acute kidney injury in hospitalized patients with chronic kidney disease

Breidthardt, Tobias and Jaeger, Cedric and Christ, Andreas and Klima, Theresia and Mosimann, Tamina and Twerenbold, Raphael and Boeddinghaus, Jasper and Nestelberger, Thomas and Badertscher, Patrick and Struck, Joachim and Bergmann, Andreas and Hartmann, Oliver and Kalbermatter, Stefan and Marenzi, Giancarlo and Mueller, Christian. (2018) Proenkephalin for the early detection of acute kidney injury in hospitalized patients with chronic kidney disease. European journal of clinical investigation, 48 (10). e12999.

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Official URL: https://edoc.unibas.ch/71170/

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Abstract

The early detection of acute kidney injury (AKI) in patients with chronic kidney disease (CKD) is an unmet clinical need. Proenkephalin (PENK) might improve the early detection of AKI.; One hundred and eleven hospitalized CKD patients undergoing radiographic contrast procedures were enrolled. PENK was measured in a blinded fashion at baseline (before contrast media administration) and on day 1 (after contrast media administration). The potential of PENK levels to predict contrast-induced AKI was the primary endpoint.; Baseline creatinine and baseline PENK were similar in AKI and no-AKI patients. In AKI patients, day 1 PENK (198 pmol/L vs 121 pmol/L, P < 0.01) was significantly higher compared to no-AKI patients. The area under the curve (AUC) for the prediction of AKI by day 1 PENK was 0.79, 95% CI: 0.70-0.87, similar to serum creatinine: 0.78, 95% CI: 0.61-0.95. Delta PENK was significantly higher in AKI compared to no-AKI patients (53 pmol/L vs 1 pmol/L, P < 0.01). The AUC for the prediction of AKI by delta PENK was high (0.92, 95%CI 0.82-1.00) and remained high for creatinine-blind AKI (0.94, 95% CI: 0.87-0.97).; Delta PENK levels improve the early detection of contrast-induced AKI in CKD patients over serial creatinine sampling. Delta PENK accelerates the detection of creatinine-blind AKI by 24 hours.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie > Klinische Outcomeforschung Kardiologie (Müller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie > Klinische Outcomeforschung Kardiologie (Müller)
UniBasel Contributors:Müller, Christian
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0014-2972
e-ISSN:1365-2362
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:09 Jul 2019 10:26
Deposited On:09 Jul 2019 10:26

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