Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish

Appenzeller-Herzog, Christian and Bánhegyi, Gabor and Bogeski, Ivan and Davies, Kelvin J. A. and Delaunay-Moisan, Agnès and Forman, Henry Jay and Görlach, Agnes and Kietzmann, Thomas and Laurindo, Francisco and Margittai, Eva and Meyer, Andreas J. and Riemer, Jan and Rützler, Michael and Simmen, Thomas and Sitia, Roberto and Toledano, Michel B. and Touw, Ivo P.. (2016) Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish. Free radical biology & medicine, 94. pp. 157-160.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/71134/

Downloads: Statistics Overview


Cellular metabolism provides various sources of hydrogen peroxide (H2O2) in different organelles and compartments. The suitability of H2O2 as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H2O2 has been discussed controversially. In this essay, we challenge the recent proposal that the ER membrane constitutes a simple barrier for H2O2 diffusion and support earlier data showing that (i) ample H2O2 permeability of the ER membrane is a prerequisite for signal transduction, (ii) aquaporin channels are crucially involved in the facilitation of H2O2 permeation, and (iii) a proper experimental framework not prone to artifacts is necessary to further unravel the role of H2O2 permeation in signal transduction and organelle biology.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften
05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molecular and Systems Toxicology (Odermatt)
UniBasel Contributors:Appenzeller-Herzog, Christian
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:17 May 2020 20:15
Deposited On:17 May 2020 20:15

Repository Staff Only: item control page