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Revised interpretation of the Hain Lifescience GenoType MTBC to differentiate Mycobacterium canettii and members of the M. tuberculosis complex

Loiseau, Chloé and Brites, Daniela and Moser, Irmgard and Coll, Francesc and Pourcel, Christine and Robbe-Austerman, Suelee and Escuyer, Vincent and Musser, Kimberlee A. and Peacock, Sharon J. and Feuerriegel, Silke and Kohl, Thomas A. and Niemann, Stefan and Gagneux, Sebastien and Köser, Claudio U.. (2019) Revised interpretation of the Hain Lifescience GenoType MTBC to differentiate Mycobacterium canettii and members of the M. tuberculosis complex. Antimicrobial agents and chemotherapy, 63 (6). e00159-19.

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Official URL: https://edoc.unibas.ch/70914/

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Abstract

Using 894 phylogenetically diverse genomes of the; Mycobacterium tuberculosis; complex (MTBC), we simulated; in silico; the ability of the Hain Lifescience GenoType MTBC assay to differentiate the causative agents of tuberculosis. Here, we propose a revised interpretation of this assay to reflect its strengths (e.g., it can distinguish some strains of; Mycobacterium canettii; and variants of; Mycobacterium bovis; that are not intrinsically resistant to pyrazinamide) and limitations (e.g.,; Mycobacterium orygis; cannot be differentiated from; Mycobacterium africanum; ).
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Research (Gagneux)
UniBasel Contributors:Loiseau, Chloé Marie and Brites, Daniela and Gagneux, Sebastien
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society for Microbiology
ISSN:0066-4804
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 Jul 2019 12:35
Deposited On:10 Jul 2019 12:35

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