Cre/loxP-based mouse models of mast cell deficiency and mast cell-specific gene inactivation

Peschke, Katrin and Dudeck, Anne and Rabenhorst, Anja and Hartmann, Karin and Roers, Axel. (2015) Cre/loxP-based mouse models of mast cell deficiency and mast cell-specific gene inactivation. In: Mast Cells. Methods and Protocols, 1220. New York, pp. 403-421.

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Over the past decades, research on in vivo functions of mast cells has largely relied on kit-mutant mouse strains. Recently, new mouse models for investigation of mast cell functions based on the Cre/loxP recombination system have been published and results in these new models challenged findings of previous studies in kit-mutant mice. Herein we describe procedures central to mast cell-specific gene inactivation and the generation of mast cell-deficient mice based on the mouse strain Mcpt5-Cre, which expresses Cre recombinase selectively in connective tissue mast cells.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Allergologie (Hartmann)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Allergologie (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Publisher:Humana Press
Series Name:Methods in molecular biology
Note:Publication type according to Uni Basel Research Database: Book item
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Last Modified:06 Jan 2021 14:35
Deposited On:01 Jul 2019 09:18

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