A case of linear porokeratosis superimposed on disseminated superficial actinic porokeratosis

Löhrer, Rebecca and Neumann-Acikel, Aysegül and Eming, Rüdiger and Hartmann, Karin and Rasokat, Heinrich and Krieg, Thomas and Happle, Rudolf and Eming, Sabine. (2010) A case of linear porokeratosis superimposed on disseminated superficial actinic porokeratosis. Case Reports in Dermatology, 2 (2). pp. 130-134.

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We present a female patient with linear porokeratosis of her right arm since childhood. At the age of 67 years she additionally developed disseminated superficial actinic porokeratosis (DSAP) involving both lower legs. This uncommon coexistence of two different types of porokeratosis fulfils the clinical criteria of a type 2 segmental manifestation of an autosomal dominant skin disorder, being superimposed on the ordinary nonsegmental lesions and reflecting loss of heterozygosity that occurred at an early developmental stage. In DSAP molecular evidence of this concept is so far lacking, but such proof has already been provided in several other autosomal dominant skin disorders. Molecular analysis of cases of type 2 segmental involvement may help elucidate the genetic defect causing DSAP.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:10 Nov 2020 16:16
Deposited On:10 Nov 2020 16:16

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