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Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E

Cheng, Laurence E. and Hartmann, Karin and Roers, Axel and Krummel, Matthew F. and Locksley, Richard M.. (2013) Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity, 38 (1). pp. 166-175.

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Official URL: https://edoc.unibas.ch/70784/

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Abstract

Mast cells are tissue-resident immune cells that play a central role in allergic disease. These contributions are largely dependent on the acquisition of antigen-specific immunoglobulin E (IgE). Despite this requirement, studies of mast cell and IgE interactions have overlooked the mechanism by which mast cells acquire IgE from the blood. To address this gap, we developed reporter IgE molecules and employed imaging techniques to study mast cell function in situ. Our data demonstrate that skin mast cells exhibit selective uptake of IgE based on perivascular positioning. Furthermore, perivascular mast cells acquire IgE by extending cell processes across the vessel wall to capture luminal IgE. These data demonstrate how tissue mast cells acquire IgE and reveal a strategy by which extravascular cells monitor blood contents to capture molecules central to cellular function.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
ISSN:1074-7613
e-ISSN:1097-4180
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Nov 2020 16:59
Deposited On:10 Nov 2020 16:59

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