Mast cells are dispensable for normal and activin-promoted wound healing and skin carcinogenesis

Antsiferova, Maria and Martin, Caroline and Huber, Marcel and Feyerabend, Thorsten B. and Förster, Anja and Hartmann, Karin and Rodewald, Hans-Reimer and Hohl, Daniel and Werner, Sabine. (2013) Mast cells are dispensable for normal and activin-promoted wound healing and skin carcinogenesis. Journal of Immunology, 191 (12). pp. 6147-6155.

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Official URL: https://edoc.unibas.ch/70778/

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The growth and differentiation factor activin A is a key regulator of tissue repair, inflammation, fibrosis, and tumorigenesis. However, the cellular targets, which mediate the different activin functions, are still largely unknown. In this study, we show that activin increases the number of mature mast cells in mouse skin in vivo. To determine the relevance of this finding for wound healing and skin carcinogenesis, we mated activin transgenic mice with CreMaster mice, which are characterized by Cre recombinase-mediated mast cell eradication. Using single- and double-mutant mice, we show that loss of mast cells neither affected the stimulatory effect of overexpressed activin on granulation tissue formation and reepithelialization of skin wounds nor its protumorigenic activity in a model of chemically induced skin carcinogenesis. Furthermore, mast cell deficiency did not alter wounding-induced inflammation and new tissue formation or chemically induced angiogenesis and tumorigenesis in mice with normal activin levels. These findings reveal that mast cells are not major targets of activin during wound healing and skin cancer development and also argue against nonredundant functions of mast cells in wound healing and skin carcinogenesis in general.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association of Immunologists
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Nov 2020 16:52
Deposited On:10 Nov 2020 16:52

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