Proposed diagnostic criteria and classification of basophilic leukemias and related disorders

Valent, Peter and Sotlar, Karl and Blatt, Katharina and Hartmann, Karin and Reiter, Andreas and Sadovnik, Irina and Sperr, Wolfgang R. and Bettelheim, Peter and Akin, Cem and Bauer, Karin and George, Tracy I. and Hadzijusufovic, Emir and Wolf, Dominik and Gotlib, Jason and Mahon, François-Xavier and Metcalfe, Dean D. and Horny, Hans Peter and Arock, Michel. (2017) Proposed diagnostic criteria and classification of basophilic leukemias and related disorders. Leukemia, 31 (4). pp. 788-797.

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Official URL: https://edoc.unibas.ch/70747/

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Basophils form a distinct cell lineage within the hematopoietic cell family. In various myeloid neoplasms, including chronic myeloid leukemia, basophilia is frequently seen. Acute and chronic basophilic leukemias, albeit rare, have also been described. However, no generally accepted criteria and classification of basophilic leukemias have been presented to date. To address this unmet need, a series of Working Conferences and other meetings were organized between March 2015 and March 2016. The current article provides a summary of consensus statements from these meetings, together with proposed criteria to delineate acute basophilic leukemia (ABL) from chronic basophilic leukemia (CBL) and primary forms of the disease where no preceding myeloid malignancy is detected, from the more common 'secondary' variants. Moreover, the term hyperbasophilia (HB) is proposed for cases with a persistent peripheral basophil count ⩾1000 per μl of blood. This condition, HB, is highly indicative of the presence of an underlying myeloid neoplasm. Therefore, HB is an important checkpoint in the diagnostic algorithm and requires a detailed hematologic investigation. In these patients, an underlying myeloid malignancy is often found and is then labeled with the appendix -baso, whereas primary cases of ABL or CBL are very rare. The criteria and classification proposed in this article should facilitate the diagnosis and management of patients with unexplained basophilia and basophil neoplasms in routine practice, and in clinical studies.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer Nature
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Apr 2020 14:10
Deposited On:12 Apr 2020 14:10

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