Eosinophils are a major source of interleukin-31 in bullous pemphigoid

Rüdrich, Urda and Gehring, Manuela and Papakonstantinou, Eleni and Illerhaus, Anja and Engmann, Judith and Kapp, Alexander and Hartmann, Karin and Meyer, N. Helge and Gibbs, Bernhard F. and Raap, Ulrike. (2018) Eosinophils are a major source of interleukin-31 in bullous pemphigoid. Acta Dermato-Venereologica, 98 (8). pp. 766-771.

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Bullous pemphigoid (BP) is characterized by substantial skin and blood eosinophilia as well as intensive pruritus. Since the pruritogenic cytokine interleukin (IL)-31 is increased in inflammatory skin diseases the aim of this study was to determine whether IL-31 plays a role in BP. Using immunofluorescence, IL-31 expression was analysed in eosinophils derived from blister fluids and skin from patients with BP and IL-31 levels in blister fluids, serum and culture supernatants were determined by enzyme-linked immunoassay (ELISA). High levels of IL-31 expression were observed in BP blister fluids, but they were only marginally elevated in BP serum compared with healthy controls. Eosinophils from either BP blister fluids or skin biopsies showed strong expression of IL-31. Furthermore, peripheral blood eosinophils from patients with BP, but not healthy controls, released high levels of IL-31, reflecting those in blister fluids. In conclusion, eosinophils are a major source of IL-31 in BP and this cytokine may contribute to itch in patients with BP.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Apr 2020 15:16
Deposited On:09 Apr 2020 15:16

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