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Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition

Shaban, Hamdy and Humeau, Yann and Herry, Cyril and Cassasus, Guillaume and Shigemoto, Ryuichi and Ciocchi, Stephane and Barbieri, Samuel and van der Putten, Herman and Kaupmann, Klemens and Bettler, Bernhard and Lüthi, Andreas. (2006) Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nature neuroscience, Vol. 9, H. 8. pp. 1028-1035.

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Official URL: http://edoc.unibas.ch/dok/A5262227

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Abstract

Pavlovian fear conditioning, a simple form of associative learning, is thought to involve the induction of associative, NMDA receptor-dependent long-term potentiation (LTP) in the lateral amygdala. Using a combined genetic and electrophysiological approach, we show here that lack of a specific GABA(B) receptor subtype, GABA(B(1a,2)), unmasks a nonassociative, NMDA receptor-independent form of presynaptic LTP at cortico-amygdala afferents. Moreover, the level of presynaptic GABA(B(1a,2)) receptor activation, and hence the balance between associative and nonassociative forms of LTP, can be dynamically modulated by local inhibitory activity. At the behavioral level, genetic loss of GABA(B(1a)) results in a generalization of conditioned fear to nonconditioned stimuli. Our findings indicate that presynaptic inhibition through GABA(B(1a,2)) receptors serves as an activity-dependent constraint on the induction of homosynaptic plasticity, which may be important to prevent the generalization of conditioned fear.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Molecular Neurobiology Synaptic Plasticity (Bettler)
UniBasel Contributors:Bettler, Bernhard
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature America
ISSN:1097-6256
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:37

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