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Plasma and serum brain-derived neurotrophic factor (BDNF) levels and their association with neurocognition in at-risk mental state, first episode psychosis and chronic schizophrenia patients

Heitz, Ulrike and Papmeyer, Martina and Studerus, Erich and Egloff, Laura and Ittig, Sarah and Andreou, Christina and Vogel, Tobias and Borgwardt, Stefan and Graf, Marc and Eckert, Anne and Riecher-Rössler, Anita. (2018) Plasma and serum brain-derived neurotrophic factor (BDNF) levels and their association with neurocognition in at-risk mental state, first episode psychosis and chronic schizophrenia patients. The World Journal of Biological Psychiatry. pp. 1-10.

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Official URL: https://edoc.unibas.ch/70695/

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Abstract

OBJECTIVES: Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive processes. Since cognitive deficits are a core feature of psychotic disorders, the investigation of BDNF levels in psychosis and their correlation with cognition has received increased attention. However, there are no studies investigating BDNF levels in individuals with an at-risk mental state (ARMS) for psychosis. Hence, the aims of the present study were: (1) assessing peripheral BDNF levels across different (potential) stages of psychosis; (2) investigating their association with cognition. METHODS: Plasma and serum BDNF levels and neuropsychological performance were assessed in 16 ARMS, six first-episode psychosis (FEP), and 11 chronic schizophrenia (CS) patients. Neuropsychological assessment covered intelligence, verbal memory, working memory, attention and executive functioning. RESULTS: Both plasma and serum BDNF levels were highest in CS, intermediate in FEP and lowest in ARMS. Multiple regression analysis revealed a significant positive association of plasma BDNF levels with planning ability across all groups. CONCLUSIONS: The lower peripheral BDNF levels in ARMS compared to FEP and CS might point towards an important drop of this neurotrophin prior to the onset of frank psychosis. The associations of peripheral BDNF with planning-abilities match previous findings.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Riecher-Rössler, Anita and Studerus, Erich
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Taylor & Francis
ISSN:1562-2975
e-ISSN:1814-1412
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:22 Aug 2019 14:22
Deposited On:03 Jun 2019 14:26

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