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Multiple introductions of Mycobacterium tuberculosis lineage 2-Beijing into Africa over centuries

Rutaihwa L, Menardo F. and Stucki D, Gygli S. M. and Ley SD, Malla B. and Feldmann J, Borrell S. and Beisel C, Middelkoop K. and Carter JE, Diero L. and Ballif M, Jugheli L. and Reither K, Fenner L. and Brites D, Gagneux S.. (2019) Multiple introductions of Mycobacterium tuberculosis lineage 2-Beijing into Africa over centuries. Frontiers in Ecology and Evolution, 7. p. 112.

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Abstract

The Lineage 2–Beijing (L2–Beijing) sub-lineage of Mycobacterium tuberculosis has received much attention due to its high virulence, fast disease progression, and association with antibiotic resistance. Despite several reports of the recent emergence of L2–Beijing in Africa, no study has investigated the evolutionary history of this sub-lineage on the continent. In this study, we used whole genome sequences of 781 L2 clinical strains from 14 geographical regions globally distributed to investigate the origins and onward spread of this lineage in Africa. Our results reveal multiple introductions of L2–Beijing into Africa linked to independent bacterial populations from East- and Southeast Asia. Bayesian analyses further indicate that these introductions occurred during the past 300 years, with most of these events pre-dating the antibiotic era. Hence, the success of L2–Beijing in Africa is most likely due to its hypervirulence and high transmissibility rather than drug resistance.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Tuberculosis Research (Gagneux)
UniBasel Contributors:Rutaihwa, Liliana and Menardo, Fabrizio and Stucki, David and Gygli, Sebastian and Ley, Serej and Feldmann, Julia and Borrell Farnov, Sonia and Jugheli, Levan and Reither, Klaus and Fenner, Lukas and Brites, Daniela and Gagneux, Sebastien
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Media
ISSN:2296-701X
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:28 May 2019 11:48
Deposited On:28 May 2019 11:48

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