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The sex ratio in amyotrophic lateral sclerosis: A population based study

Manjaly, Zita-Rose and Scott, Kirsten M. and Abhinav, Kumar and Wijesekera, Lokesh and Ganesalingam, Jeban and Goldstein, Laura H. and Janssen, Anna and Dougherty, Andrew and Willey, Emma and Stanton, Biba R. and Turner, Martin R. and Ampong, Mary-Ann and Sakel, Mohammed and Orrell, Richard W. and Howard, Robin and Shaw, Chris E. and Leigh, P. Nigel and Al-Chalabi, Ammar. (2010) The sex ratio in amyotrophic lateral sclerosis: A population based study. Amyotrophic Lateral Sclerosis, 11 (5). pp. 439-442.

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Official URL: https://edoc.unibas.ch/70629/

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Abstract

Replicable risk factors for ALS include increasing age, family history and being male. The male: female ratio has been reported as being between 1 and 3. We tested the hypothesis that the sex ratio changes with age in a population register covering the south-east of England. The sex ratio before and after the age of 51 years was compared using a Z-test for proportions. Kendall's tau was used to assess the relationship between age group and sex ratio using incidence and prevalence data. Publicly available data from Italian and Irish population registers were compared with results. There was a significant difference in the proportion of females with ALS between those in the younger group (30.11%) and those in the older group (43.66%) (p = 0.013). The adjusted male: female ratio dropped from 2.5 in the younger group to 1.4 in the older group using prevalence data (Kendall's tau = -0.73, p = 0.039). Similar ratios were found in the Italian but not the Irish registry. We concluded that sex ratios in ALS may change with age. Over-representation of younger patients in clinic registers may explain the variation in sex ratios between studies. Menopause may also play a role.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Allergologie (Hartmann)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Allergologie (Hartmann)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Manjaly Thomas, Zita-Rose
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Taylor & Francis
ISSN:1471-180X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Nov 2020 09:13
Deposited On:13 Nov 2020 09:13

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