e-POCT: improving health outcomes of febrile children in Tanzania through innovative point-of-care technologies at the primary care level

Keitel, Kristina. e-POCT: improving health outcomes of febrile children in Tanzania through innovative point-of-care technologies at the primary care level. 2017, Doctoral Thesis, University of Basel, Faculty of Science.


Official URL: http://edoc.unibas.ch/diss/DissB_13217

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Febrile illnesses are the leading cause for pediatric outpatient consultations in low-resource settings. Only a small percentage of children require antibiotic treatment or inpatient care. The key challenge for clinicians is to identify this minority with serious presentations among the large number of children with self-limiting infections. Health workers tend to prescribe antibiotics in the vast majority of cases, “to be on the safe side”, given the lack of adequate diagnostic tools.
To address these challenges electronic clinical decision algorithms, based on the World Health Organization Integrated Management of Childhood Illnesses (IMCI) guidelines, had been developed by Swiss TPH. However, opportunities for improvement remain, especially related to the identification of children with serious infections. Host biomarkers, that can help identify children with bacterial infections, had not been considered within the IMCI strategy. In addition, point-of-care tests (POCTs) are available that may help detect children with severe presentations where clinical signs lack diagnostic accuracy, e.g. hemoglobin testing for identifying children with severe anemia. The aim of this project was to improve the clinical outcome and rational antimicrobial prescription among children with acute febrile illnesses through the development and evaluation of a novel electronic disease management tool (ePOCT). The project had two major components: i) development of a novel, evidence-based electronic algorithm, ePOCT, that integrates clinical signs with point-of-care biomarkers, and ii) evaluation of ePOCT through a controlled, randomized, non-inferiority trial in Tanzania.
Advisors:Tanner, Marcel and D'Acremont, Valérie and Hamer, David
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Malaria Vaccines (Tanner)
UniBasel Contributors:Keitel, Kristina and Tanner, Marcel
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:13217
Thesis status:Complete
Number of Pages:1 Online-Ressource (XII, 184 Seiten)
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edoc DOI:
Last Modified:05 Feb 2020 05:30
Deposited On:17 Sep 2019 14:13

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