A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans

Domeier, Mary Ellen and Morse, Daniel P. and Knight, Scott W. and Portereiko, Michael and Bass, Brenda L. and Mango, Susan E.. (2000) A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans. Science, 289 (5486). pp. 1928-1930.

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Official URL: https://edoc.unibas.ch/70572/

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Double-stranded RNA (dsRNA) inhibits expression of homologous genes by a process involving messenger RNA degradation. To gain insight into the mechanism of degradation, we examined how RNA interference is affected by mutations in the smg genes, which are required for nonsense-mediated decay. For three of six smg genes tested, mutations resulted in animals that were initially silenced by dsRNA but then recovered; wild-type animals remained silenced. The levels of target messenger RNAs were restored during recovery, and RNA editing and degradation of the dsRNA were identical to those of the wild type. We suggest that persistence of RNA interference relies on a subset of smg genes.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Mango)
UniBasel Contributors:Mango, Susan Elizabeth
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Nov 2020 09:21
Deposited On:13 Nov 2020 09:21

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