edoc

The TBP-like factor CeTLF is required to activate RNA polymerase II transcription during C. elegans embryogenesis

Kaltenbach, Linda and Horner, Michael A. and Rothman, Joel H. and Mango, Susan E.. (2000) The TBP-like factor CeTLF is required to activate RNA polymerase II transcription during C. elegans embryogenesis. Molecular Cell, 6 (3). pp. 705-713.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/70571/

Downloads: Statistics Overview

Abstract

Metazoans possess two TATA-binding protein homologs, the general transcription factor TBP and a related factor called TLF. Four models have been proposed for the role of TLF in RNA polymerase II (Pol II) transcription: (1) TLF and TBP function redundantly, (2) TLF antagonizes TBP, (3) TLF is a tissue-specific TBP, or (4) TLF and TBP have distinct activities. Here we report that CeTLF is required to express a subset of Pol II genes and associates with at least one of these genes in vivo. CeTLF is also necessary to establish bulk transcription during early embryogenesis. Since CeTLF and CeTBP are expressed at comparable levels in the same cells, these findings suggest CeTLF performs a unique function in activating Pol II transcription distinct from that of CeTBP.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Mango)
UniBasel Contributors:Mango, Susan Elizabeth
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
ISSN:1097-2765
e-ISSN:1097-4164
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:13 Nov 2020 15:21
Deposited On:13 Nov 2020 15:21

Repository Staff Only: item control page