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Locking the genome: nuclear organization and cell fate

Meister, Peter and Mango, Susan E. and Gasser, Susan M.. (2011) Locking the genome: nuclear organization and cell fate. Current Opinion in Genetics & Development, 21 (2). pp. 167-174.

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Official URL: https://edoc.unibas.ch/70550/

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Abstract

The differentiation of pluripotent or totipotent cells into various differentiated cell types is accompanied by a restriction of gene expression patterns, alteration in histone and DNA methylation, and changes in the gross nuclear organization of eu- and heterochromatic domains. Several recent studies have coupled genome-wide mapping of histone modifications with changes in gene expression. Other studies have examined changes in the subnuclear positioning of tissue-specific genes upon transcriptional induction or repression. Here we summarize intriguing correlations of the three phenomena, which suggest that in some cases causal relationships may exist.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Mango)
UniBasel Contributors:Mango, Susan Elizabeth
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0959-437X
e-ISSN:1879-0380
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Nov 2020 10:03
Deposited On:16 Nov 2020 10:03

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