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Chimeric Streptavidins as Host Proteins for Artificial Metalloenzymes

Pellizzoni, Michela M. and Schwizer, Fabian and Wood, Christopher W. and Sabatino, Valerio and Cotelle, Yoann and Matile, Stefan and Woolfson , Derek N. and Ward, Thomas R.. (2018) Chimeric Streptavidins as Host Proteins for Artificial Metalloenzymes. ACS Catalysis, 8 (2). pp. 1476-1484.

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Official URL: https://edoc.unibas.ch/70529/

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Abstract

The streptavidin scaffold was expanded with well-structured naturally occurring motifs. These chimeric scaffolds were tested as host for biotinylated catalysts as artificial metalloenzymes (ArM) for asymmetric transfer hydrogenation, ring closing metathesis and anion- π catalysis. The additional second coordination sphere elements significantly influence both the activity and the selectivity of the resulting hybrid catalysts. These findings lead to identify propitious chimeric streptavidins for future directed evolution efforts of artificial metalloenzymes.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie
05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ward, Thomas R. R. and Pellizzoni, Michela Maria and Schwizer, Fabian and Sabatino, Valerio and Cotelle, Yoann and Matile, Stefan
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:1331-7768
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:22 May 2019 09:23
Deposited On:22 May 2019 09:09

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