edoc

Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging : a multi-cohort analysis

Fiorito, Giovanni and McCrory, Cathal and Robinson, Oliver and Carmeli, Cristian and Rosales, Carolina Ochoa and Zhang, Yan and Colicino, Elena and Dugué, Pierre-Antoine and Artaud, Fanny and McKay, Gareth J. and Jeong, Ayoung and Mishra, Pashupati P. and Nøst, Therese H. and Krogh, Vittorio and Panico, Salvatore and Sacerdote, Carlotta and Tumino, Rosario and Palli, Domenico and Matullo, Giuseppe and Guarrera, Simonetta and Gandini, Martina and Bochud, Murielle and Dermitzakis, Emmanouil and Muka, Taulant and Schwartz, Joel and Vokonas, Pantel S. and Just, Allan and Hodge, Allison M. and Giles, Graham G. and Southey, Melissa C. and Hurme, Mikko A. and Young, Ian and McKnight, Amy Jayne and Kunze, Sonja and Waldenberger, Melanie and Peters, Annette and Schwettmann, Lars and Lund, Eiliv and Baccarelli, Andrea and Milne, Roger L. and Kenny, Rose A. and Elbaz, Alexis and Brenner, Hermann and Kee, Frank and Voortman, Trudy and Probst-Hensch, Nicole and Lehtimäki, Terho and Elliot, Paul and Stringhini, Silvia and Vineis, Paolo and Polidoro, Silvia and Bios Consortium, and Lifepath consortium, . (2019) Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging : a multi-cohort analysis. Aging, 11 (7). pp. 2045-2070.

[img] PDF - Published Version
Available under License CC BY (Attribution).

923Kb

Official URL: https://edoc.unibas.ch/70366/

Downloads: Statistics Overview

Abstract

Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries.The four biological aging biomarkers were associated with education and different sets of risk factors independently, and the magnitude of the effects differed depending on the biomarker and the predictor. On average, the effect of low education on epigenetic aging was comparable with those of other lifestyle-related risk factors (obesity, alcohol intake), with the exception of smoking, which had a significantly stronger effect.Our study shows that low education is an independent predictor of accelerated biological (epigenetic) aging and that epigenetic clocks appear to be good candidates for disentangling the biological pathways underlying social inequalities in healthy aging and longevity.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Jeong, Ayoung and Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:McGraw-Hill
ISSN:0272-3808
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:07 May 2019 07:24
Deposited On:07 May 2019 07:24

Repository Staff Only: item control page