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Performance of the point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for follow-up after treatment of S. mansoni infection in Eritrean refugees

Neumayr, Andreas and Chernet, Afona and Sydow, Véronique and Kling, Kerstin and Kuenzli, Esther and Marti, Hanspeter and Paris, Daniel H. and Nickel, Beatrice and Labhardt, Niklaus D.. (2019) Performance of the point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for follow-up after treatment of S. mansoni infection in Eritrean refugees. Travel medicine and infectious disease, 28. pp. 59-63.

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Official URL: https://edoc.unibas.ch/70363/

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Abstract

Point-of-care circulating cathodic antigen (POC-CCA) urine cassette testing has become a popular approach to screen for Schistosoma infection. Since the test is also increasingly used for following-up of treatment success, we assessed the assay's diagnostic accuracy after praziquantel treatment of S. mansoni infection among Eritrean refugees in Switzerland.; In our preceding study, 107 asymptomatic Eritrean refugees in Switzerland were screened for schistosomiasis by stool microscopy, serology, and POC-CCA urine testing. Individuals screened positive by any method were treated with praziquantel and invited for a follow-up visit, repeating the same diagnostic procedures one year after treatment. The POC-CCA baseline and follow-up results were analyzed against the 'baseline microscopy positive cases' (= the most reliably true positive cases) and the 'baseline microscopy plus serology negative cases at baseline and follow-up' (= the most reliably true negative cases).; Complete diagnostic baseline and follow-up sampling was available from 48 participants. Compared to most reliably true positive cases at baseline, POC-CCA testing had a sensitivity of 90%. Compared to most reliably true negative cases, POC-CCA testing had a specificity of 73.9%.; We conclude that the POC-CCA urine test is valuable for screening but its use is not suitable for routine follow-up after treatment.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Medical Services (Neumayr)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Medical Services (Neumayr)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Clinical Research (Reither)
UniBasel Contributors:Neumayr, Andreas and Chernet, Afona and Sydow, Véronique and Kling, Kerstin and Marti, Hanspeter and Paris, Daniel Henry and Nickel, Beatrice and Labhardt, Niklaus
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1477-8939
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:07 May 2019 07:19
Deposited On:07 May 2019 07:19

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