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Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades : the European Community Respiratory Health Survey

Lytras, Theodore and Kogevinas, Manolis and Kromhout, Hans and Carsin, Anne-Elie and Antó, Josep Maria and Bentouhami, Hayat and Weyler, Joost and Heinrich, Joachim and Nowak, Dennis and Urrutia, Isabel and Martínez-Moratalla, Jesús and Gullón, José Antonio and Vega, Antonio Pereira and Raherison Semjen, Chantal and Pin, Isabelle and Demoly, Pascal and Leynaert, Bénédicte and Villani, Simona and Gíslason, Thorarinn and Svanes, Øistein and Holm, Mathias and Forsberg, Bertil and Norbäck, Dan and Mehta, Amar J. and Probst-Hensch, Nicole and Benke, Geza and Jogi, Rain and Torén, Kjell and Sigsgaard, Torben and Schlünssen, Vivi and Olivieri, Mario and Blanc, Paul D. and Watkins, John and Bono, Roberto and Buist, A. Sonia and Vermeulen, Roel and Jarvis, Deborah and Zock, Jan-Paul. (2019) Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades : the European Community Respiratory Health Survey. Occupational and environmental medicine, 76 (4). pp. 222-229.

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Official URL: https://edoc.unibas.ch/70358/

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Abstract

Chronic bronchitis (CB) is an important chronic obstructive pulmonary disease (COPD)-related phenotype, with distinct clinical features and prognostic implications. Occupational exposures have been previously associated with increased risk of CB but few studies have examined this association prospectively using objective exposure assessment. We examined the effect of occupational exposures on CB incidence in the European Community Respiratory Health Survey.; Population samples aged 20-44 were randomly selected in 1991-1993, and followed up twice over 20 years. Participants without chronic cough or phlegm at baseline were analysed. Coded job histories during follow-up were linked to the ALOHA Job Exposure Matrix, generating occupational exposure estimates to 12 categories of chemical agents. Their association with CB incidence over both follow-ups was examined with Poisson models using generalised estimating equations.; 8794 participants fulfilled the inclusion criteria, contributing 13 185 observations. Only participants exposed to metals had a higher incidence of CB (relative risk (RR) 1.70, 95% CI 1.16 to 2.50) compared with non-exposed to metals. Mineral dust exposure increased the incidence of chronic phlegm (RR 1.72, 95% CI 1.43 to 2.06). Incidence of chronic phlegm was increased in men exposed to gases/fumes and to solvents and in women exposed to pesticides.; Occupational exposures are associated with chronic phlegm and CB, and the evidence is strongest for metals and mineral dust exposure. The observed differences between men and women warrant further investigation.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:BMJ Publ. Group
ISSN:1351-0711
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:07 May 2019 07:15
Deposited On:07 May 2019 07:15

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