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Novel prostaglandin receptor modulators - part II: EP receptor modulators; a patent review (2002 - 2012)

Flesch, Daniel and Merk, Daniel and Lamers, Christina and Schubert-Zsilavecz, Manfred. (2013) Novel prostaglandin receptor modulators - part II: EP receptor modulators; a patent review (2002 - 2012). Expert opinion on therapeutic patents, 23 (2). pp. 233-267.

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Official URL: https://edoc.unibas.ch/70331/

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Abstract

Prostaglandins and their G-protein-coupled receptors play numerous physiological and pathophysiological roles, especially in inflammation and its resolution. The variety of effects mediated by prostanoids makes prostanoid receptors valuable drug targets and the research on prostaglandin receptor modulators is intensive. The physiological and pathophysiological effects of prostaglandin E(2) are especially complex and numerous. The four subtypes of EP receptor have gained a lot of industrial and academic interest, in particular EP(2) and EP(4) for various indications.; Evaluation of the patent activity over the last decade (2002 - 2012) illustrates several potent compounds targeting the distinct prostaglandin E(2) receptors. Many novel methods for the use of EP receptor modulators have been developed, in addition to the classical indications for agents modulating the arachidonic acid cascade such as pain and inflammation.; Several EP targeting agents with good potency and selectivity have been developed but their pharmacological use and utility has not yet been satisfactorily investigated. More research is necessary, and clinical use of these agents might therefore take some more time.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molekulare Pharmazie (Ricklin)
UniBasel Contributors:Lamers, Christina
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Taylor & Francis
ISSN:1354-3776
e-ISSN:1744-7674
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Nov 2020 10:58
Deposited On:16 Nov 2020 10:58

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