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Of mice and men: The factor H protein family and complement regulation

Pouw, R. B. and Vredevoogd, D. W. and Kuijpers, T. W. and Wouters, D.. (2015) Of mice and men: The factor H protein family and complement regulation. Molecular immunology, 67 (1). pp. 12-20.

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Abstract

For decades immunological research has relied, with variable success, on mouse models to investigate diseases and possible therapeutic interventions. With the approval of the first therapeutic antibody targeting complement, called eculizumab, as therapy in paroxysmal nocturnal hemoglobinuria (PNH) and more recently atypical hemolytic uremic syndrome (aHUS), the viability of targeting the complement system was demonstrated. The potent, endogenous complement regulators have become of increasing interest as templates for designing and developing new therapeutics. Recently, complement inhibitors based on (parts of) the human complement regulator factor H (FH) are being examined for therapeutic intervention in inflammatory conditions. The first step to evaluate the potency of a new drug is often testing it in a mouse model for the target disease. However, translating results to human conditions requires a good understanding of similarities and, more importantly, differences between the human and mouse complement system and particularly regulation. This review will provide a comprehensive overview of the complement regulator FH and its closely related proteins and current views on their role in mice and men.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molekulare Pharmazie (Ricklin)
UniBasel Contributors:Pouw, Richard Benjamin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1872-9142
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:31 Jul 2019 11:35
Deposited On:10 May 2019 14:46

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