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Histone dynamics in DNA damage and repair

Hauer, Michael H.. Histone dynamics in DNA damage and repair. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_13083

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Abstract

The overall perspective of my PhD project was to uncover the mechanisms that generate DNA damage-dependent chromatin mobility and to identify the players implicated in this process. To tackle this problem, I investigated the physical characteristics and composition of chromatin under DNA damaging conditions. I see my PhD project divided into two mayor themes: (I) Identifying physical chromatin changes under DNA damaging conditions (mainly using microscopic assays) (II) Addressing changes in chromatin protein composition upon DNA damage and DNA damage checkpoint activation (using Western blot analysis, genome-wide nucleosome mapping, microscopy and quantitative mass spectrometry)
Advisors:Gasser, Susan M. and Owen-Hughes, Tom
Faculties and Departments:09 Associated Institutions > Friedrich Miescher Institut FMI > Quantitative Biology > Nuclear organization in development and genome stability (Gasser)
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:13083
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:1 Online-Ressource (179 Seiten)
Language:English
Identification Number:
Last Modified:07 Jun 2019 09:50
Deposited On:07 Jun 2019 09:49

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