edoc

Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder

Sonuga-Barke, Edmund J. S. and Brookes, Keeley-Joanne and Buitelaar, Jan and Anney, Richard and Bitsakou, Paraskevi and Baeyens, Dieter and Buschgens, Cathelijne and Chen, Wai and Christiansen, Hanna and Eisenberg, Jacques and Kuntsi, Jonna and Manor, Iris and Meliá, Amanda and Mulligan, Aisling and Rommelse, Nanda and Müller, Ueli C. and Uebel, Henrik and Banaschewski, Tobias and Ebstein, Richard and Franke, Barbara and Gill, Michael and Miranda, Ana and Oades, Robert D. and Roeyers, Herbert and Rothenberger, Aribert and Sergeant, Joseph and Steinhausen, Hans Christoph and Thompson, Margaret and Taylor, Eric and Asherson, Philip and Faraone, Stephen V.. (2008) Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 147, H. 3. pp. 316-319.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5250691

Downloads: Statistics Overview

Abstract

A major goal of genetic studies of attention deficit hyperactivity disorder (ADHD) is to identify individual characteristics that might help segregate the disorder's inherent heterogeneity. [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] recently reported a potentially important association between two dopamine-related risk polymorphisms (DRD4 variable number tandem repeat (VNTR) in exon 3 and DAT1 VNTR in the 3' UTR) and lowered IQ in ADHD. The objective of the current study was to replicate the [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] findings in a clinical sample and to extend the analysis to a large range of alternative SNP markers of putative ADHD risk alleles identified in a recent study [Brookes et al. (2006); Mol Genet 11:934-953]. Participants were 1081 children and adolescents with a research-confirmed combined type ADHD diagnosis and 1300 unaffected siblings who took part in the International Multi-centre ADHD Genetics (IMAGE) project. They were recruited from multiple settings from across Europe: Belgium, Britain, Germany, Ireland, Israel, Netherlands, Spain and Switzerland. The results were that ADHD was associated with reduced IQ. However, there was no association between the two dopamine-related risk polymorphisms and IQ in either the probands or their siblings. Furthermore, other selected genetic markers previously demonstrated to be associated with ADHD in this sample were not associated with IQ. This large scale study with a clinically ascertained and regorously diagnosed sample failed to replicate the association between genetic polymorphisms in the dopamine system and IQ in ADHD. We also observed no association of other SNPs with IQ in ADHD.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:1552-4841
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:37

Repository Staff Only: item control page