Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD

Zhou, Kaixin and Chen, Wai and Buitelaar, Jan and Banaschewski, Tobias and Oades, Robert D. and Franke, Barbara and Sonuga-Barke, Edmund and Ebstein, Richard and Eisenberg, Jacques and Gill, Michael and Manor, Iris and Miranda, Ana and Mulas, Fernando and Roeyers, Herbert and Rothenberger, Aribert and Sergeant, Joseph and Steinhausen, Hans-Christoph and Lasky-Su, Jessica and Taylor, Eric and Brookes, Keeley J. and Xu, Xiaohui and Neale, Benjamin M. and Rijsdijk, Fruhling and Thompson, Margaret and Asherson, Philip and Faraone, Stephen V.. (2008) Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 147B, H. 8. pp. 1481-1487.

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Official URL: http://edoc.unibas.ch/dok/A5250680

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Previous studies have found heterogeneous association between DAT1-3'-UTR-VNTR and attention deficit hyperactivity disorder (ADHD). Various proportions of conduct disorder (CD) comorbidity in their ADHD samples may partially explain the observational discrepancies. Evidence for this comes from family and twin studies which found ADHD probands with CD (ADHD + CD) are genetically different from those without CD (ADHD - CD). Genotypes of 20 DAT1 markers were analyzed in 576 trios, consisting of 141 ADHD + CD and 435 ADHD - CD. In addition to the classical TDT test, a specific genetic heterogeneity test was performed to identify variants that have different transmission patterns in the two phenotypic subgroups. After multiple-test correction, rs40184 and rs2652511 were significant in TDT tests. Further heterogeneity test found the two SNPs had a significant transmission pattern difference between ADHD + CD and ADHD - CD children, indicating that DAT1 has a significantly greater genetic influence on ADHD without CD. Although the result needs further replications, it does highlight the importance of selecting genetically homogeneous samples for molecular genetic analyses of ADHD.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:37

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