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Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan

Sonuga-Barke, Edmund J. S. and Lasky-Su, Jessica and Neale, Benjamin M. and Oades, Robert and Chen, Wai and Franke, Barbara and Buitelaar, Jan and Banaschewski, Tobias and Ebstein, Richard and Gill, Michael and Anney, Richard and Miranda, Ana and Mulas, Fernando and Roeyers, Herbert and Rothenberger, Aribert and Sergeant, Joseph and Steinhausen, Hans Christoph and Thompson, Margaret and Asherson, Philip and Faraone, Stephen V.. (2008) Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 147B, H. 8. pp. 1359-1368.

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Official URL: http://edoc.unibas.ch/dok/A5250667

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Abstract

Studies of gene x environment (G x E) interaction in ADHD have previously focused on known risk genes for ADHD and environmentally mediated biological risk. Here we use G x E analysis in the context of a genome-wide association scan to identify novel genes whose effects on ADHD symptoms and comorbid conduct disorder are moderated by high maternal expressed emotion (EE). SNPs (600,000) were genotyped in 958 ADHD proband-parent trios. After applying data cleaning procedures we examined 429,981 autosomal SNPs in 909 family trios. ADHD symptom severity and comorbid conduct disorder was measured using the Parental Account of Childhood Symptoms interview. Maternal criticism and warmth (i.e., EE) were coded by independent observers on comments made during the interview. No G x E interactions reached genome-wide significance. Nominal effects were found both with and without genetic main effects. For those with genetic main effects 36 uncorrected interaction P-values were
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:1552-4841
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:37

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