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Synthesis of a Forssman antigen derivative for use in a conjugate vaccine

Feng, Jianhao and Hevey, Rachel and Ling, Chang-Chun. (2011) Synthesis of a Forssman antigen derivative for use in a conjugate vaccine. Carbohydrate Research, 346 (17). pp. 2650-2662.

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Official URL: https://edoc.unibas.ch/70098/

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Abstract

The total chemical synthesis of a Forssman antigen analog is described. The pentasaccharide contains a functionalized tether which should facilitate future conjugation with immunogenic proteins. We found that the total synthesis can be efficiently achieved by following a convergent 2+3 strategy, and using N-Troc protected GalNAc thioglycoside as a donor.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Molekulare Pharmazie (Ernst)
05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molekulare Pharmazie (Ricklin)
UniBasel Contributors:Hevey, Rachel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0008-6215
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Nov 2020 10:21
Deposited On:16 Nov 2020 10:21

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