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Replication of a rare protective allele in the noradrenaline transporter gene and ADHD

Xu, X. and Hawi, Z. and Brookes, K. J. and Anney, R. and Bellgrove, M. and Franke, B. and Barry, E. and Chen, W. and Kuntsi, J. and Banaschewski, T. and Buitelaar, J. and Ebstein, R. and Fitzgerald, M. and Miranda, A. and Oades, R. D. and Roeyers, H. and Rothenberger, A. and Sergeant, J. and Sonuga-Barke, E. and Steinhausen, H.-C. and Faraone, S. V. and Gill, M. and Asherson, P.. (2008) Replication of a rare protective allele in the noradrenaline transporter gene and ADHD. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 147B, H. 8. pp. 1564-1567.

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Official URL: http://edoc.unibas.ch/dok/A5250665

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Abstract

Replication is a key to resolving whether a reported genetic association represents a false positive finding or an actual genetic risk factor. In a previous study screening 51 candidate genes for association with ADHD in a multi-centre European sample (the IMAGE project), two single nucleotide polymorphisms (SNPs) within the norepinephrine transporter (SLC6A2) gene were found to be associated with attention deficit hyperactivity disorder (ADHD). The same SNP alleles were also reported to be associated with ADHD in a separate study from the Massachusetts General Hospital in the US. Using two independent samples of ADHD DSM-IV combined subtype trios we attempted to replicate the reported associations with SNPs rs11568324 and rs3785143 in SLC6A2. Significant association of the two markers was not observed in the two independent replication samples. However, across all four datasets the overall evidence of association with ADHD was significant (for SNP rs11568324 P = 0.0001; average odds ratio = 0.33; for SNP rs3785143 P = 0.008; average odds ratio = 1.3). The data were consistent for rs11568324, suggesting the existence of a rare allele conferring protection for ADHD within the SLC6A2 gene. Further investigations should focus on identifying the mechanisms underlying the protective effect.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:1552-4841
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:37

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