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Genome-wide association scan of attention deficit hyperactivity disorder

Neale, Benjamin M. and Lasky-Su, Jessica and Anney, Richard and Franke, Barbara and Zhou, Kaixin and Maller, Julian B. and Vasquez, Alejandro Arias and Asherson, Philip and Chen, Wai and Banaschewski, Tobias and Buitelaar, Jan and Ebstein, Richard and Gill, Michael and Miranda, Ana and Oades, Robert D. and Roeyers, Herbert and Rothenberger, Aribert and Sergeant, Joseph and Steinhausen, Hans Christoph and Sonuga-Barke, Edmund and Mulas, Fernando and Taylor, Eric and Laird, Nan and Lange, Christoph and Daly, Mark and Faraone, Stephen V.. (2008) Genome-wide association scan of attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 147B, H. 8. pp. 1337-1344.

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Official URL: http://edoc.unibas.ch/dok/A5250661

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Abstract

Results of behavioral genetic and molecular genetic studies have converged to suggest that genes substantially contribute to the development of attention deficit/hyperactivity disorder (ADHD), a common disorder with an onset in childhood. Yet, despite numerous linkage and candidate gene studies, strongly consistent and replicable association has eluded detection. To search for ADHD susceptibility genes, we genotyped approximately 600,000 SNPs in 958 ADHD affected family trios. After cleaning the data, we analyzed 438,784 SNPs in 2,803 individuals comprising 909 complete trios using ADHD diagnosis as phenotype. We present the initial TDT findings as well as considerations for cleaning family-based TDT data. None of the SNP association tests achieved genome-wide significance, indicating that larger samples may be required to identify risk loci for ADHD. We additionally identify a systemic bias in family-based association, and suggest that variable missing genotype rates may be the source of this bias.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:1552-4841
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:37

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