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Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder

Unschuld, P. G. and Ising, M. and Erhardt, A. and Lucae, S. and Kloiber, S. and Kohli, M. and Salyakina, D. and Welt, T. and Kern, N. and Lieb, R. and Uhr, M. and Binder, E. B. and Müller-Myhsok, B. and Holsboer, F. and Keck, M. E.. (2007) Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 144B, H. 4. pp. 424-429.

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Official URL: http://edoc.unibas.ch/dok/A5253183

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Abstract

Anxiety disorders and specifically panic disorder (PD) are caused by complex interactions of environmental and genetic factors. The latter comprise many different genes, from which those involved in serotonergic neurotransmission have received particular attention. Here we report the results from an association candidate-gene approach, where we analyzed 15 single nucleotide polymorphisms (SNPs) within the gene coding for the serotonin-receptor 2A (HTR2A) in patients suffering from PD and a control sample. We found that the SNP rs2296972 shows an association between the number of T-alleles and severity of symptoms in PD. By performing tests according to the Fisher product method (FPM), an association between HTR2A and the personality trait reward dependence could be shown. Most pronounced effects were observable for the SNPs rs2770304, rs6313, and rs6311. Furthermore, the polymorphisms rs3742278, rs2296972, and rs2770292 form a haplotype, which may be associated with higher susceptibility for PD. These results further underline a possible important role of genetic variations within the system controlling serotonergic neurotransmission for the development and course of disease in PD.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Lieb, Roselind
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:1552-4841
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:37

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